In our new preprint, we describe a novel methodology for (1) identifying the most probable "core" tract trajectory for two arbitrary brain regions, and (2) estimating tract-specific anisotropy (TSA) at all points along this trajectory. We describe the outcomes of regressing this TSA metric against participants' age and sex. Our hope is that this new method can serve as a complement to the popular TBSS approach, where researchers desire to investigate effects specific to a pre-established set of ROIs.
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